HCID 14500295, compound → [2-tert-Butyl-4-(4-fluorophenyl)-5-phenylfuran-3-yl]methanol

HRID 1761971Notes

Reaction equation

HRID 1761971 reaction equation
[H-].[Al+3].[Li+].[H-].[H-].[H-].[F:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[C:15]([C:29](OCC)=[O:30])=[C:16]([C:25]([CH3:28])([CH3:27])[CH3:26])[O:17][C:18]=2[C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[CH:10][CH:9]=1>CCOCC>[C:25]([C:16]1[O:17][C:18]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[C:14]([C:11]2[CH:12]=[CH:13][C:8]([F:7])=[CH:9][CH:10]=2)[C:15]=1[CH2:29][OH:30])([CH3:28])([CH3:26])[CH3:27]

Participants

4

Reactant 2

HCID 14500295HCID 14500295, compoundHCID 21226445Aluminium lithium hydride

Product 1

HCID 14500301[2-tert-Butyl-4-(4-fluorophenyl)-5-phenylfuran-3-yl]methanol

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

Under a dry nitrogen atmosphere, to a slurry of 1.15 g (30.4 mmol) of lithium aluminum hydride in 50 ml of dry ether at about 0° was added 5.56 g (15.2 mmol) of 4-(4-fluorophenyl)-2-tert.-butyl-5-phenyl-3-furyl-carboxylic acid, ethyl ester in 25 ml of dry ether. The mixture was heated at reflux for one-half hour.

Workup

  1. temperatureThe mixture was heated
  2. temperatureat reflux for one-half hour

Sources & evidence

ORD record
ord-4a20bd316a8c4a848c1d797cda85f1ae
Source dataset
uspto-grants-1989_05
Patent number
US04829081

Reaction notes

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