2-Amino-2-methyl-1,3-propanediol → HCID 54185837, compound

HRID 1762014Notes

Reaction equation

HRID 1762014 reaction equation
[CH3:1][S:2]([O:5][CH2:6][C:7]([NH:11][CH2:12][C:13]1[CH:14]=[C:15]2[C:24](=[C:25]3[C:30]=1[CH:29]=[CH:28][CH:27]=[CH:26]3)[CH:23]=[CH:22][C:21]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]2=1)([CH3:10])[CH2:8][OH:9])(=[O:4])=[O:3].C1C2C=CC3C(=CC=C4C=3C=CC=C4)C=2C=C(C=O)C=1.NC(C)(CO)CO>>[CH3:1][S:2]([O:5][CH2:6][C:7]([NH:11][CH2:12][C:13]1[CH:30]=[CH:29][C:28]2[CH:27]=[CH:26][C:25]3[C:24]([C:15]=2[CH:14]=1)=[CH:23][CH:22]=[C:21]1[C:16]=3[CH:17]=[CH:18][CH:19]=[CH:20]1)([CH3:10])[CH2:8][OH:9])(=[O:4])=[O:3]

Participants

4

Reactant 3

HCID 15312-Amino-2-methyl-1,3-propanediolHCID 15599326Chrysene-3-carbaldehydeHCID 540960872-((6-Chrysenylmethyl)amino)-2-methyl-1,3-propanediol methanesulfonate

Product 1

HCID 54185837HCID 54185837, compound

Procedure

Using the reductive amination procedure outlined in 1C, chrysene-3-carbaldehyde (19G) and 2-amino-2-methyl-1,3-propanediol (Aldrich) gave 2-((3-chrysenylmethyl)amino)-2-methyl-1,3-propanediol methanesulfonate mp 180°-182° (dec), (EtOH/Et2O), (C,H,N,S).

Sources & evidence

ORD record
ord-d2db9dbca48449dfb7ea06a113d4872f
Source dataset
uspto-grants-1989_05
Patent number
US04829090

Reaction notes

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