2-Aminothiazole → HCID 14252769, compound

HRID 1762030Notes

Reaction equation

[NH2:1][CH:2]([C:8]#[N:9])[C:3]([O:5][CH2:6][CH3:7])=[O:4].C([O-])([O-])O[CH2:12][CH3:13].[NH2:16][C:17]1[S:18]C=[CH:20][N:21]=1>>[NH2:9][C:8]1[N:21]([C:17]2[S:18][CH:12]=[CH:13][N:16]=2)[CH:20]=[N:1][C:2]=1[C:3]([O:5][CH2:6][CH3:7])=[O:4]

Participants

Reactant 3

HCID 21552-Aminothiazole

HCID 288716Ethyl 2-amino-2-cyanoacetate

HCID 53630039Ethylorthoformate

Product 1

HCID 14252769HCID 14252769, compound

Procedure

Following the procedure described in Reference Example 7, the desired compound was synthesized using ethyl α-aminocyanoacetate, ethyl orthoformate and 2-aminothiazole as raw materials. m.p.: 120° to 123° C.

Sources & evidence

ORD record: ord-1bbd0049143249e5bec7592d5e5328d0
Source dataset: uspto-grants-1989_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04830660

Reaction notes

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