2-Amino-4-methylthiazole → HCID 14516776, compound

HRID 1762032Notes

Reaction equation

HRID 1762032 reaction equation
[NH2:1][CH:2]([C:8]#[N:9])[C:3]([O:5][CH2:6][CH3:7])=[O:4].C([O-])([O-])O[CH2:12][CH3:13].[NH2:16][C:17]1[S:18][CH:19]=[C:20](C)[N:21]=1>>[NH2:9][C:8]1[N:21]([C:17]2[S:18][CH:19]=[C:12]([CH3:13])[N:16]=2)[CH:20]=[N:1][C:2]=1[C:3]([O:5][CH2:6][CH3:7])=[O:4]

Participants

4

Reactant 3

HCID 741432-Amino-4-methylthiazoleHCID 288716Ethyl 2-amino-2-cyanoacetateHCID 53630039Ethylorthoformate

Product 1

HCID 14516776HCID 14516776, compound

Procedure

The desired compound was synthesized following the procedures described in Reference Example 7 by using ethyl α-aminocyanoacetate, ethyl orthoformate and 2-amino-4-methylthiazole as raw materials. m.p.: 152° to 155° C.

Sources & evidence

ORD record
ord-fac00546efca49f3bd229f7815b866f3
Source dataset
uspto-grants-1989_05
Patent number
US04830660

Reaction notes

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