HCID 14516783, compound → HCID 14516793, compound

HRID 1762039Notes

Reaction equation

HRID 1762039 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[N:7]=[CH:8][N:9]([C:15]2[S:16][CH:17]=[N:18][N:19]=2)[C:10]=1[S:11]([NH2:14])(=[O:13])=[O:12])=[O:5])[CH3:2].[CH3:20][O:21][C:22]1[CH:27]=[C:26]([O:28][CH3:29])[N:25]=[C:24]([N:30](C2C=CC=CC=2)[C:31](=O)[O-:32])[N:23]=1>C(#N)C>[CH3:29][O:28][C:26]1[CH:27]=[C:22]([O:21][CH3:20])[N:23]=[C:24]([NH:30][C:31]([NH:14][S:11]([C:10]2[N:9]([C:15]3[S:16][CH:17]=[N:18][N:19]=3)[CH:8]=[N:7][C:6]=2[C:4]([O:3][CH2:1][CH3:2])=[O:5])(=[O:13])=[O:12])=[O:32])[N:25]=1

Participants

4

Reactant 2

HCID 14516783HCID 14516783, compoundHCID 22104197HCID 22104197, compound

Product 1

HCID 14516793HCID 14516793, compoundYield 62.6%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

0.23 g of 1,8-diazobicyclo(5,4,0)-7-undecene was added dropwise to a mixture of 0.45 g of 4-ethoxycarbonyl-1-(1,3,4-thiadiazol-2-yl)imidazole-5-sulfonamide, 0.41 g of N-(4,6-dimethoxypyrimidine-2-yl)phenylcarbamate and 5 ml of acetonitrile. After stirring the reaction mixture at room temperature for 20 minutes, 20 ml of ice water was added thereto and the mixture was filtered. The filtrate was made acidic with use of conc. hydrochloric acid, and resulting precipitated crystals were collected by filtration, washed with water and ethyl ether, and dried to obtain 0.45 g of the title compound. m.p.: 169° to 171° C.

Workup

  1. filtrationthe mixture was filtered
  2. customresulting
  3. customprecipitated crystals
  4. filtrationwere collected by filtration
  5. washwashed with water and ethyl ether
  6. customdried

Sources & evidence

ORD record
ord-9c8b4f252f3041eba5b5f04d0673f3a6
Source dataset
uspto-grants-1989_05
Patent number
US04830660

Reaction notes

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