Phenylacetyl chloride → HCID 135767482, compound

HRID 1762073Notes

Reaction equation

HRID 1762073 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:16]=[C:15]2[N:10]([C:11](=[O:21])[NH:12][C:13]3[CH2:20][CH2:19][NH:18][CH2:17][C:14]=32)[N:9]=1.[C:22]1([CH2:28][C:29](Cl)=[O:30])[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>CCOCC>[C:22]1([CH2:28][C:29]([N:18]2[CH2:19][CH2:20][C:13]3[NH:12][C:11](=[O:21])[N:10]4[N:9]=[C:8]([C:3]5[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=5[F:1])[N:16]=[C:15]4[C:14]=3[CH2:17]2)=[O:30])[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

Participants

4

Reactant 2

HCID 7679Phenylacetyl chlorideHCID 135767477HCID 135767477, compound

Product 1

HCID 135767482HCID 135767482, compoundYield 85%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A mixture of 2-(2-fluorophenyl)-7,8,9,10-tetrahydropyrido[3,4-e][1,2,4]triazolo[1,5-c]pyrimidin-5(6H)one (0.57 g, Example 15) and phenylacetylchloride (3 mL) is heated under nitrogen at 120° for 4 hours. The mixture is diluted with ether (30 mL) and the solid collected, washed with ether and air dried to afford pure 9-phenylacetyl-2-(2-fluorophenyl)-7,8,9,10-tetrahydropyrido[3,4-e][1,2,4]triazolo[1,5-c]pyrimidin-5(6H)one, m.p. 310°-313°, in 85% yield.

Workup

  1. temperatureis heated under nitrogen at 120° for 4 hours
  2. customthe solid collected
  3. washwashed with ether and air
  4. customdried

Sources & evidence

ORD record
ord-d3b161a7b30846d8ad59d7f35976298f
Source dataset
uspto-grants-1989_05
Patent number
US04831013

Reaction notes

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