Potassium Carbonate → HCID 13961089, compound

HRID 1762082Notes

Reaction equation

HRID 1762082 reaction equation
[CH:1]([C:4]1([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[OH:22])[C:9](=[O:10])[N:8]([CH3:11])[C:7]2[CH:12]=[CH:13][CH:14]=[CH:15][C:6]=2[S:5]1)([CH3:3])[CH3:2].[Br:23][CH2:24][CH2:25][O:26][CH2:27][CH2:28]Br.C(=O)([O-])[O-].[K+].[K+]>CC(=O)CC>[CH:1]([C:4]1([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[O:22][CH2:28][CH2:27][O:26][CH2:25][CH2:24][Br:23])[C:9](=[O:10])[N:8]([CH3:11])[C:7]2[CH:12]=[CH:13][CH:14]=[CH:15][C:6]=2[S:5]1)([CH3:3])[CH3:2]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 21521Bis(2-bromoethyl) etherHCID 13961088HCID 13961088, compound

Product 1

HCID 13961089HCID 13961089, compound

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

9.4 g (30 mmol) of 3,4-dihydro-2-isopropyl-4-methyl-2-(2-hydroxyphenyl)-2H-1,4-benzothiazin-3-one are boiled for 8 hours under reflux with 22 g (94 mmol) of 1,5-dibromo-3-oxapentane and 12.9 g (90 mmol) of potassium carbonate in 75 ml of 2-butanone. The mixture is then filtered with suction, and the filtrate is concentrated, finally in a high vacuum. This gives 12.4 g of an almost colorless oil.

Workup

  1. filtrationThe mixture is then filtered with suction
  2. concentrationthe filtrate is concentrated, finally in a high vacuum

Sources & evidence

ORD record
ord-0fae6c5078a94310aa9389eea064b094
Source dataset
uspto-grants-1989_05
Patent number
US04831028

Reaction notes

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