反应详情

Ten grams of methyl 4-[2-(4-chlorobenzamido)ethoxy]benzoate was dissolved in 100 ml of hot ethanol. A solution of 2.4 g of sodium hydroxide in 20 ml of water was added to the above ethanolic solution and the mixture was heated to reflux for 2 hours. The reaction solution was concentrated in vacuo, 100 ml of water was added to the residue, the mixture was neutralized with 10% hydrochloric acid, crystals separated out were collected by filtration, washed with water, dried and recrystallised from ethanol to give 8.4 g (yield: 87%) of crystalline product. M.p. 219°-220° C.

1. temperaturethe mixture was heated
2. temperatureto reflux for 2 hours
3. concentrationThe reaction solution was concentrated in vacuo, 100 ml of water
4. additionwas added to the residue
5. customseparated out
6. filtrationwere collected by filtration
7. washwashed with water
8. customdried
9. customrecrystallised from ethanol