Sodium Hydroxide → HCID 14097620, compound

Participants

Reaction Steps

Ten grams of methyl 4-[2-(4-chlorobenzamido)ethoxy]benzoate was dissolved in 100 ml of hot ethanol. A solution of 2.4 g of sodium hydroxide in 20 ml of water was added to the above ethanolic solution and the mixture was heated to reflux for 2 hours. The reaction solution was concentrated in vacuo, 100 ml of water was added to the residue, the mixture was neutralized with 10% hydrochloric acid, crystals separated out were collected by filtration, washed with water, dried and recrystallised from ethanol to give 8.4 g (yield: 87%) of crystalline product. M.p. 219°-220° C.

Provenance & Evidence