HCID 20042526, compound → HCID 20042530, compound

HRID 1762191Notes

Reaction equation

HRID 1762191 reaction equation
[NH2:1][C:2]1[C:7]([O:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([O:16]COC)[CH:11]=2)=[CH:6][CH:5]=[CH:4][N:3]=1>S(=O)(=O)(O)O>[NH2:1][C:2]1[C:7]([O:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([OH:16])[CH:11]=2)=[CH:6][CH:5]=[CH:4][N:3]=1

Participants

3

Reactant 1

HCID 20042526HCID 20042526, compound

Product 1

HCID 20042530HCID 20042530, compoundYield 77.3%

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

A mixture of 2-amino-3-(3-methoxymethoxybenzyloxy)pyridine (7.6 g) and 10% sulfuric acid (150 ml) was stirred at room temperature for 4 hours and the resulting precipitates were collected by filtration. The obtained sulfate was treated with an aqueous solution of sodium bicarbonate and the precipitates were collected by filtration, washed with water, and air-dried to give 2-amino-3-(3-hydroxybenzyloxy)pyridine (4.88 g).

Workup

  1. customthe resulting precipitates
  2. filtrationwere collected by filtration
  3. additionThe obtained sulfate was treated with an aqueous solution of sodium bicarbonate
  4. filtrationthe precipitates were collected by filtration
  5. washwashed with water
  6. customair-dried

Sources & evidence

ORD record
ord-5dbd55d9cf1c455497ab466ab3319f56
Source dataset
uspto-grants-1989_05
Patent number
US04831041

Reaction notes

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