Acetic-formic anhydride → 2-Formamido-6-methylbenzyl alcohol

HRID 1762194Notes

Reaction equation

HRID 1762194 reaction equation
[CH:1](OC(=O)C)=[O:2].[NH2:7][C:8]1[CH:15]=[CH:14][CH:13]=[C:12]([CH3:16])[C:9]=1[CH2:10][OH:11]>C1C=CC=CC=1.CCCCCC>[CH:1]([NH:7][C:8]1[CH:15]=[CH:14][CH:13]=[C:12]([CH3:16])[C:9]=1[CH2:10][OH:11])=[O:2]

Participants

5

Reactant 2

HCID 75269Acetic-formic anhydrideHCID 15339417(2-Amino-6-methylphenyl)methanol

Product 1

HCID 143684522-Formamido-6-methylbenzyl alcoholYield 84.9%

Reagents, catalysts & solvents 2

HCID 241BenzeneSolventHCID 8058HexaneSolvent

Procedure

Acetic formic anhydride (1.85 g) was added to a solution of 2-amino-6-methylbenzyl alcohol (2.74 g) in benzene (55 ml) at room temperature. After being stirred for 2 hours, the mixture was diluted with n-hexane (10 ml) and the precipitates were collected by filtration to give 2-formamido-6-methylbenzyl alcohol (2.8 g).

Workup

  1. filtrationthe precipitates were collected by filtration

Sources & evidence

ORD record
ord-31200514c4f54d2a9954e0aaa3bb2148
Source dataset
uspto-grants-1989_05
Patent number
US04831041

Reaction notes

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