Methyl Isocyanate → 6-Methyl-2-(3-methyl ureido)benzyl alcohol

HRID 1762195Notes

Reaction equation

HRID 1762195 reaction equation
[NH2:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([CH3:10])[C:3]=1[CH2:4][OH:5].[CH3:11][N:12]=[C:13]=[O:14]>C1C=CC=CC=1>[CH3:10][C:6]1[C:3]([CH2:4][OH:5])=[C:2]([NH:1][C:13]([NH:12][CH3:11])=[O:14])[CH:9]=[CH:8][CH:7]=1

Participants

4

Reactant 2

HCID 12228Methyl IsocyanateHCID 15339417(2-Amino-6-methylphenyl)methanol

Product 1

HCID 143684536-Methyl-2-(3-methyl ureido)benzyl alcoholYield 64.1%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

A mixture of 2-amino-6-methylbenzyl alcohol (0.274 g) and methyl isocyanate (0.11 g) in benzene (5.2 ml) was stirred at room temperature for 15 minutes. The resulting precipitates were collected by filtration and dried to give 6-methyl-2-(3-methyl ureido)benzyl alcohol (0.24 g).

Workup

  1. customThe resulting precipitates
  2. filtrationwere collected by filtration
  3. customdried

Sources & evidence

ORD record
ord-3167749fd55e4931b3c06f29c9259668
Source dataset
uspto-grants-1989_05
Patent number
US04831041

Reaction notes

Loading…