Potassium Carbonate → HCID 14368485, compound

HRID 1762207Notes

Reaction equation

HRID 1762207 reaction equation
C([O:4][CH2:5][C:6]1[C:11]([NH:12][C:13](=[O:15])[CH3:14])=[CH:10][CH:9]=[CH:8][C:7]=1[NH:16][C:17](=[O:19])[CH3:18])(=O)C.C(=O)([O-])[O-].[K+].[K+]>CO>[C:13]([NH:12][C:11]1[CH:10]=[CH:9][CH:8]=[C:7]([NH:16][C:17](=[O:19])[CH3:18])[C:6]=1[CH2:5][OH:4])(=[O:15])[CH3:14]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 14368484HCID 14368484, compound

Product 1

HCID 14368485HCID 14368485, compoundYield 82.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 2,6-di(acetamido)benzyl acetate (0.97 g) in methanol (70 ml) was added an aqueous solution (1.8 ml) of potassium carbonate (608 mg) and the mixture was stirred at room temperature for 1 hour. After methanol was evaporated under reduced pressure, the resultant residue was subjected to column chromatography on silica gel (18 g) and eluted with a mixture of chloroform and methanol (20:1) to give 2,6-di(acetamido)benzyl alcohol (0.67 g).

Workup

  1. customAfter methanol was evaporated under reduced pressure
  2. washeluted with a mixture of chloroform and methanol (20:1)

Sources & evidence

ORD record
ord-17faac9a683d46bcaf6c3f4b035cf392
Source dataset
uspto-grants-1989_05
Patent number
US04831041

Reaction notes

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