Potassium Carbonate → HCID 14368383, compound

HRID 1762211Notes

Reaction equation

HRID 1762211 reaction equation
C([O:4][CH2:5][C:6]1[CH:26]=[CH:25][CH:24]=[CH:23][C:7]=1[CH2:8][O:9][C:10]1[C:11]2[N:12]([C:16]([CH2:20][C:21]#[CH:22])=[C:17]([CH3:19])[N:18]=2)[CH:13]=[CH:14][CH:15]=1)(=O)C.C(=O)([O-])[O-].[K+].[K+]>O.CO>[OH:4][CH2:5][C:6]1[CH:26]=[CH:25][CH:24]=[CH:23][C:7]=1[CH2:8][O:9][C:10]1[C:11]2[N:12]([C:16]([CH2:20][C:21]#[CH:22])=[C:17]([CH3:19])[N:18]=2)[CH:13]=[CH:14][CH:15]=1

Participants

5

Reactant 2

HCID 11430Potassium CarbonateHCID 14368350HCID 14368350, compound

Product 1

HCID 14368383HCID 14368383, compoundYield 56.5%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent2×

Procedure

A mixture of 8-(2-acetoxymethylbenzyloxy)-2-methyl-3-(2-propynyl)imidazo [1,2-a]pyridine (0.36 g) and potassium carbonate (0.214 g) in water (1.8 ml) and methanol (10 ml) was stirred at room temperature for 1.2 hours and then diluted with water. The resulting precipitates were collected by filtration and recrystallized from ethyl acetate to give 8-(2-hydroxymethylbenzyloxy)-2-methyl-3-(2-propynyl)imidazo[1,2-a]pyridine (0.179 g).

Workup

  1. customThe resulting precipitates
  2. filtrationwere collected by filtration
  3. customrecrystallized from ethyl acetate

Sources & evidence

ORD record
ord-0b78dfc7273a47a29e0e774ad4f9a0c3
Source dataset
uspto-grants-1989_05
Patent number
US04831041

Reaction notes

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