Nitric Acid → m-(Trifluoromethyl)nitrobenzene

HRID 1762307Notes

Reaction equation

HRID 1762307 reaction equation
[N+:1]([O-:4])([O-])=[O:2].[K+].[N+]([O-])(O)=O.C(O)(=O)C.[N+]([O-])(O)=O.[C:18]1([C:24]([F:27])([F:26])[F:25])[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>S(=O)(=O)(O)O>[N+:1]([C:20]1[CH:19]=[C:18]([C:24]([F:27])([F:26])[F:25])[CH:23]=[CH:22][CH:21]=1)([O-:4])=[O:2]

Participants

6

Reactant 4

HCID 944Nitric AcidHCID 7368(Trifluoromethyl)benzeneHCID 24434Potassium NitrateHCID 86584207Acetic acid nitric acid

Product 1

HCID 7386m-(Trifluoromethyl)nitrobenzene

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent2×

Procedure

The nitration step (a) may be effected by using various nitrating agents such as concentrated nitric-sulfuric acid, potassium nitrate--sulfuric acid and nitric acid-acetic acid. The preferred nitrating agent is connected nitric-sulfuric acid. The reaction is carried out by slowly adding fuming nitric acid to a mixture of benzotrifluoride in concentrated sulfuric acid while maintaining the temperature of the reaction between 0° to 40° C., preferably 20°-30° C. When the addition is complete, the reaction is allowed to continue for 1 to 2 hours, preferably 1 hour at room temperature. 3-Nitrobenzotrifluoride is isolated from the reaction mixture by conventional techniques.

Workup

  1. temperaturewhile maintaining
  2. customthe temperature of the reaction between 0° to 40° C.
  3. custompreferably 20°-30° C
  4. additionWhen the addition

Sources & evidence

ORD record
ord-96e6305d77074995a7d9d52a6e14d2a1
Source dataset
uspto-grants-1989_05
Patent number
US04831193

Reaction notes

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