反应详情

温度

190 °C

An amount of 0.84 g of to 3,5,6-trifluoro-4-methoxyphthalic acid and 10 ml of water were placed in a sealed tube, replaced with nitrogen and heated at 190° C. for 8 hours. After completion of the reaction, the mixture was cooled to room temperature and concentrated, whereby crystals were precipitated. The crystals were filtered, washed (chloroform 5 ml) and then dried. As colorless crystals, 0.48 g of 2,4,5-trifluoro-3-hydroxybenzoic acid was obtained.

1. customAfter completion of the reaction
2. temperaturethe mixture was cooled to room temperature
3. concentrationconcentrated
4. customwhereby crystals were precipitated
5. filtrationThe crystals were filtered
6. washwashed (chloroform 5 ml)
7. customdried