1,2-Benzenedicarboxylic acid, 3,4,6-trifluoro-5-methoxy- → 2,4,5-Trifluoro-3-hydroxybenzoic Acid

Participants

Reaction Conditions

Reaction Steps

An amount of 0.84 g of to 3,5,6-trifluoro-4-methoxyphthalic acid and 10 ml of water were placed in a sealed tube, replaced with nitrogen and heated at 190° C. for 8 hours. After completion of the reaction, the mixture was cooled to room temperature and concentrated, whereby crystals were precipitated. The crystals were filtered, washed (chloroform 5 ml) and then dried. As colorless crystals, 0.48 g of 2,4,5-trifluoro-3-hydroxybenzoic acid was obtained.

Provenance & Evidence