Hydrochloric Acid → HCID 14305253, compound

HRID 1762404Notes

Reaction equation

HRID 1762404 reaction equation
[CH:1]1([CH:7]([N:11]2[C:15]([C:16]([O:18]C)=[O:17])=[CH:14][N:13]=[CH:12]2)[CH2:8][CH2:9][CH3:10])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[OH-].[Na+].Cl>O>[CH:1]1([CH:7]([N:11]2[C:15]([C:16]([OH:18])=[O:17])=[CH:14][N:13]=[CH:12]2)[CH2:8][CH2:9][CH3:10])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 20040722HCID 20040722, compound

Product 1

HCID 14305253HCID 14305253, compoundYield 64.7%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

A solution of 24 parts of methyl 1-(1-cyclohexylbutyl)-1H-imidazole-5-carboxylate in 50 parts of a sodium hydroxide solution 50% and 50 parts of water was stirred for 1.5 hours at reflux temperature. After cooling, the mixture was poured into 500 parts of water and the whole was neutralized with concentrated hydrochloric acid. The precipitated product was filtered off and dried, yielding 12.8 parts (64.7%) of 1-(1-cyclohexylbutyl)-1H-imidazole-5-carboxylic acid; mp. 201.7° C. (compound 27).

Workup

  1. temperatureat reflux temperature
  2. temperatureAfter cooling
  3. filtrationThe precipitated product was filtered off
  4. customdried

Sources & evidence

ORD record
ord-100d99b7c33343c79d669b0305c88fcc
Source dataset
uspto-grants-1989_05
Patent number
US04832732

Reaction notes

Loading…