Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Cyanogen Bromide | HCID 10476 | — |
| Reactant | 4-Chloro-2-methylphenol | HCID 14855 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | HCID 14501401 | HCID 14501401 | — |
Reaction Steps
4-chloro-2-methyl phenol (10g, 0.07 mol) and cyanogen bromide (7.4g, 0.07 mol) were stirred in acetone at 0° C. and triethylamine (9.7 ml, 0.07 mol) was added dropwise. The mixture was stirred at 0° C. for a further 2 hours, then filtered. The filtrate was concentrated using a rotary evaporator to leave the desired product as a fawn solid. This was used without further purification. The melting point of the product, after recrystallisation from ethyl acetate/hexane, was found to be 60° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04833137 |
|---|
| Source dataset | uspto-grants-1989_05 |
|---|
| ORD ID | ord-768c28c51f80443f846bec42112fc1f9 |
|---|
| Source note | uspto-grants-1989_05 |
|---|
