Dimethylformamide dimethyl acetal → HCID 20040894, compound

HRID 1762442Notes

Reaction equation

HRID 1762442 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]2[C:9]([CH3:12])=[N:10][NH:11][C:3]=12.[CH3:13]OC(OC)N(C)C>C1(C)C=CC=CC=1>[Cl:1][C:2]1[C:3]2[C:4](=[C:9]([CH3:12])[N:10]([CH3:13])[N:11]=2)[N:5]=[C:6]([CH3:8])[CH:7]=1

Participants

4

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 178426080HCID 178426080, compound

Product 1

HCID 20040894HCID 20040894, compoundYield 15%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

7-Chloro-3,5-dimethyl-1H-pyrazolo[4,3-b]pyridine (900 mg) and dimethylformamide dimethyl acetal (1.06 ml) in dry toluene (10 ml) were heated at reflux for 4 hours. The solvent was removed under reduced pressure and the brown oily residue chromatographed on silica gel eluting with 50:50 ether/pentane to give the title compound (150 mg, 15%).

Workup

  1. temperatureat reflux for 4 hours
  2. customThe solvent was removed under reduced pressure
  3. customthe brown oily residue chromatographed on silica gel eluting with 50:50 ether/pentane

Sources & evidence

ORD record
ord-e4a2f2efa0f14db5beb2d1c30d381d29
Source dataset
uspto-grants-1989_05
Patent number
US04833136

Reaction notes

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