Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1H-1,2,4-Triazole | HCID 9257 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | HCID 13504092 | HCID 13504092 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 13504093 | HCID 13504093 | — |
Reaction Steps
1,2,4-1H-triazole was added to a stirred suspension of sodium hydride (0.86 g, 50% dispersion, washed with petroleum ether to remove oil) in dry dimethylformamide (40 cm3). After stirring for 1.5 hours, the oxirane (formed in (b) above) dissolved in dimethylformamide (5 cm3) was added slowly. The mixture was heated at 100° C. for 2 days, then cooled and poured into water, neutralised with dilute hydrochloric acid and the product extracted into ether, which was dried (MgSO4) and concentrated by evaporation of the solvent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04833159 |
|---|
| Source dataset | uspto-grants-1989_05 |
|---|
| ORD ID | ord-b16013528065450984cea7a56a23dd6a |
|---|
| Source note | uspto-grants-1989_05 |
|---|
