Hydrochloric Acid → HCID 13504093, compound

HRID 1762477Notes

Reaction equation

HRID 1762477 reaction equation
[NH:1]1[CH:5]=[N:4][CH:3]=[N:2]1.[H-].[Na+].[F:8][C:9]([F:31])([F:30])[C:10]1[CH:15]=[CH:14][C:13]([C:16]2([C:20]3[CH:25]=[CH:24][C:23]([C:26]([F:29])([F:28])[F:27])=[CH:22][CH:21]=3)[CH:18]([CH3:19])[O:17]2)=[CH:12][CH:11]=1.Cl>CN(C)C=O.O>[F:8][C:9]([F:30])([F:31])[C:10]1[CH:15]=[CH:14][C:13]([C:16]([C:20]2[CH:25]=[CH:24][C:23]([C:26]([F:29])([F:28])[F:27])=[CH:22][CH:21]=2)([OH:17])[CH:18]([N:1]2[CH:5]=[N:4][CH:3]=[N:2]2)[CH3:19])=[CH:12][CH:11]=1

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 92571H-1,2,4-TriazoleHCID 24758Sodium hydrideHCID 13504092HCID 13504092, compound

Product 1

HCID 13504093HCID 13504093, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent2×

Conditions

Temperature
100 °C

Procedure

1,2,4-1H-triazole was added to a stirred suspension of sodium hydride (0.86 g, 50% dispersion, washed with petroleum ether to remove oil) in dry dimethylformamide (40 cm3). After stirring for 1.5 hours, the oxirane (formed in (b) above) dissolved in dimethylformamide (5 cm3) was added slowly. The mixture was heated at 100° C. for 2 days, then cooled and poured into water, neutralised with dilute hydrochloric acid and the product extracted into ether, which was dried (MgSO4) and concentrated by evaporation of the solvent.

Workup

  1. additionwas added slowly
  2. temperaturecooled
  3. extractionthe product extracted into ether, which
  4. dry with materialwas dried (MgSO4)
  5. concentrationconcentrated by evaporation of the solvent

Sources & evidence

ORD record
ord-b16013528065450984cea7a56a23dd6a
Source dataset
uspto-grants-1989_05
Patent number
US04833159

Reaction notes

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