HCID 178418361, compound → HCID 178463861, compound

HRID 1762486Notes

Reaction equation

HRID 1762486 reaction equation
[ClH:1].Cl.[CH2:3]([N:5](CC1C=CC=CC=1)[CH2:6][CH2:7][C:8]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([C:17](=[NH:20])[NH:18][CH3:19])[CH:15]=2)[NH:10][CH:9]=1)[CH3:4].[H][H]>C(O)C.[Pd]=O>[ClH:1].[ClH:1].[CH2:3]([NH:5][CH2:6][CH2:7][C:8]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([C:17](=[NH:20])[NH:18][CH3:19])[CH:15]=2)[NH:10][CH:9]=1)[CH3:4]

Participants

5

Reactant 2

HCID 178418361HCID 178418361, compoundHCID 178463860HCID 178463860, compound

Product 1

HCID 178463861HCID 178463861, compoundYield 142.7%

Reagents, catalysts & solvents 2

HCID 5083724Palladium monoxideCatalystHCID 702EthanolSolvent

Procedure

The product of Stage (i) (0.18 g) dissolved in absolute ethanol (25 ml) was hydrogenated at room temperature and pressure over 10% palladium oxide on charcoal. After the uptake of hydrogen had ceased the catalyst was removed by filtration and the filtrate reduced to dryness. The residue was recrystallised from a mixture of ethanol and ethyl acetate to give the title compound as a powder (0.1 g), m.p. 244°-246°.

Workup

  1. customwas hydrogenated at room temperature
  2. customwas removed by filtration
  3. customThe residue was recrystallised from a mixture of ethanol and ethyl acetate

Sources & evidence

ORD record
ord-5aa66833a15146e89707acebe7bf7808
Source dataset
uspto-grants-1989_05
Patent number
US04833153

Reaction notes

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