Acetic Acid → HCID 178464550, compound

HRID 1762490Notes

Reaction equation

HRID 1762490 reaction equation
[ClH:1].I.[CH3:3][N:4]([CH3:20])[CH2:5][CH2:6][C:7]1[C:15]2[C:10](=[CH:11][CH:12]=[C:13]([C:16](SC)=[NH:17])[CH:14]=2)[NH:9][CH:8]=1.[C:21](O)(=O)[CH3:22].C([NH2:27])C>C(Cl)(Cl)Cl>[ClH:1].[ClH:1].[CH3:3][N:4]([CH3:20])[CH2:5][CH2:6][C:7]1[C:15]2[C:10](=[CH:11][CH:12]=[C:13]([C:16](=[NH:27])[NH:17][CH2:21][CH3:22])[CH:14]=2)[NH:9][CH:8]=1

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 6341EthylamineHCID 20041370HCID 20041370, compound

Product 1

HCID 178464550HCID 178464550, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent2×

Procedure

The product of Stage (i) (1.0 g) was suspended in chloroform (25 ml) and acetic acid (0.5 ml) was added, followed by ethylamine (0.2 g) in chloroform (10 ml). The solution was stirred at room temperature for 3 h. The resulting suspension was collected, washed with diethyl ether (1 l) and dried in vacuo at 20° for 18 h to give a solid (0.5 g) which was recrystallised from methanol-ethyl acetate (1:3) to give the pure title compound as a solid (0.09 g), m.p. 261°-263°

Workup

  1. customThe resulting suspension was collected
  2. washwashed with diethyl ether (1 l)
  3. customdried in vacuo at 20° for 18 h

Sources & evidence

ORD record
ord-3dc9535b0df14a37937e93d4ae0fbb13
Source dataset
uspto-grants-1989_05
Patent number
US04833153

Reaction notes

Loading…