1-Chloro-2-methylpropan-2-ol → HCID 20041126, compound

Participants

Reaction Steps

The compound was also obtained, inter alia, by a two-stage synthesis from 3-methylxanthine, which was first reacted with 1-chloro-2-hydroxy-2-methylpropane to give 7-(2-hydroxy-2-methylpropyl)-3-methylxanthine (melting point: 268°-269° C.; yield 51% of theory), the product then being alkylated in the 1-position with 1-chloro-5-hydroxy-5-methylhexane from Example 1a analogously to Example 5b to give the end product (yield: 79.5% of theory).

Provenance & Evidence