1-Chloro-2-methylpropan-2-ol → HCID 20041126, compound

HRID 1762548Notes

Reaction equation

HRID 1762548 reaction equation
[CH3:1][N:2]1[C:10]2[N:9]=[CH:8][NH:7][C:6]=2[C:5](=[O:11])[NH:4][C:3]1=[O:12].Cl[CH2:14][C:15]([OH:18])([CH3:17])[CH3:16]>>[OH:18][C:15]([CH3:17])([CH3:16])[CH2:14][N:7]1[C:6]2[C:5](=[O:11])[NH:4][C:3](=[O:12])[N:2]([CH3:1])[C:10]=2[N:9]=[CH:8]1

Participants

3

Reactant 2

HCID 684091-Chloro-2-methylpropan-2-olHCID 706393-Methylxanthine

Product 1

HCID 20041126HCID 20041126, compoundYield 51%

Procedure

The compound was also obtained, inter alia, by a two-stage synthesis from 3-methylxanthine, which was first reacted with 1-chloro-2-hydroxy-2-methylpropane to give 7-(2-hydroxy-2-methylpropyl)-3-methylxanthine (melting point: 268°-269° C.; yield 51% of theory), the product then being alkylated in the 1-position with 1-chloro-5-hydroxy-5-methylhexane from Example 1a analogously to Example 5b to give the end product (yield: 79.5% of theory).

Workup

  1. customThe compound was also obtained

Sources & evidence

ORD record
ord-95a7c8bc0fcb4ed2813e7beacffc9953
Source dataset
uspto-grants-1989_05
Patent number
US04833146

Reaction notes

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