Bromide ion → HCID 13747694, compound

HRID 1762550Notes

Reaction equation

HRID 1762550 reaction equation
[CH2:1]([N:3]1[C:11]2[N:10]=[CH:9][N:8]([CH3:12])[C:7]=2[C:6](=[O:13])[N:5]([CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][C:19](=[O:21])[CH3:20])[C:4]1=[O:22])[CH3:2].[CH3:23][Mg]Cl.[Br-].C(N1C2N=CNC=2C(=O)N(CCCCCC(O)(C)C)C1=O)C.CBr.CI.CS([O-])(=O)=O.S(OC)(OC)(=O)=O.C(N1C2N=CN(C)C=2C(=O)N(CCCCC=C(C)C)C1=O)C>O>[CH2:1]([N:3]1[C:11]2[N:10]=[CH:9][N:8]([CH3:12])[C:7]=2[C:6](=[O:13])[N:5]([CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][C:19]([OH:21])([CH3:23])[CH3:20])[C:4]1=[O:22])[CH3:2]

Participants

11

Reactant 9

HCID 259Bromide ionHCID 6323Methyl BromideHCID 6328Methyl iodideHCID 6497Dimethyl SulfateHCID 85257MethanesulfonateHCID 15298100HCID 15298100, compoundHCID 20041116HCID 20041116, compoundHCID 20041117HCID 20041117, compoundHCID 178418332HCID 178418332, compound

Product 1

HCID 13747694HCID 13747694, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The same compound was also obtained by reacting 3-ethyl-7-methyl-1-(6-oxoheptyl)-xanthine with methylmagnesium chloride or bromide analogously to Example 9, methylating 3-ethyl-1-(6-hydroxy-6-methylheptyl)-xanthine with methyl bromide, methyl iodide, a methyl sulfonate or dimethyl sulfate according to Example 3, and adding water onto the olefinic double bond of 3-ethyl-7-methyl-1(6-methyl-5-heptenyl)-xanthine in accordance with the following Example 14.

Workup

  1. customThe same compound was also obtained

Sources & evidence

ORD record
ord-7ff730b226f74cf6b05223c8f34e4276
Source dataset
uspto-grants-1989_05
Patent number
US04833146

Reaction notes

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