反应详情

5.0 g (26.0 mmol) of crude 2-(6-methoxyindan-1-yl)ethanol are dissolved in 50 ml of dichloromethane and, while cooling with ice, 3.6 g (31 mmol) of methanesulphonic acid chloride and 3.1 g (31 mmol) of triethylamine are added dropwise. The mixture is stirred at room temperature for 3 hours, the triethylammonium chloride which has precipitated is filtered off and the filtrate is extracted by shaking with ice-water. The organic phases are washed with saturated sodium chloride solution, dried over magnesium sulphate and concentrated by evaporation at 40° under reduced pressure. Methanesulphonic acid 2-(6-methoxyindan-1-yl)ethyl ester is obtained which can be used without further purification.

1. additionare added dropwise
2. customthe triethylammonium chloride which has precipitated
3. filtrationis filtered off
4. extractionthe filtrate is extracted
5. stirringby shaking with ice-water
6. washThe organic phases are washed with saturated sodium chloride solution
7. dry with materialdried over magnesium sulphate
8. concentrationconcentrated by evaporation at 40° under reduced pressure