反应详情

A mixture of 12.32 g of the product of Step A, 0.6 g of p-toluene sulfonic acid and 120 ml of toluene was refluxed for 45 minutes and was cooled and evaporated to dryness under reduced pressure. The residue was chromatographed over silica gel and was eluted with a 7-3 n-hexane-ethyl acetate mixture containing 1% o acetic acid to obtain 8.94 g of (1R, cis, ΔZ) 2,2-dimethyl-3-(3-cyclopropylmethoxy-3-oxo-1-propenyl) cyclopropane-carboxylic acid melting at 106° C.

1. temperaturewas refluxed for 45 minutes
2. temperaturewas cooled
3. customevaporated to dryness under reduced pressure
4. customThe residue was chromatographed over silica gel
5. washwas eluted with a 7-3 n-hexane-ethyl acetate mixture
6. additioncontaining 1% o acetic acid