Hydrochloric Acid → HCID 178524783, compound

HRID 1762801Notes

Reaction equation

HRID 1762801 reaction equation
[OH-].[Na+].C[O:4][C:5]([C:7]1[N:11]([CH2:12][C:13]2[CH:18]=[C:17]([F:19])[CH:16]=[C:15]([F:20])[CH:14]=2)[C:10]([SH:21])=[N:9][CH:8]=1)=[O:6].Cl>O>[F:20][C:15]1[CH:14]=[C:13]([CH:18]=[C:17]([F:19])[CH:16]=1)[CH2:12][N:11]1[C:7]([C:5]([OH:6])=[O:4])=[CH:8][N:9]=[C:10]1[SH:21]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 178498871HCID 178498871, compound

Product 1

HCID 178524783HCID 178524783, compoundYield 93.1%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of sodium hydroxide (2.70 g, 0.0674 mole) in water (110 ml) was added to 1-(3,5-difluorobenzyl)-2-mercaptoimidazole-5-carboxylic acid methyl ester (6.39 g, 0.0225 mole) and the resulting solution was stirred for 2 hours. The solution was cooled in ice, acidified to pH 2 with 3N hydrochloric acid and the product was filtered and dried. The product was recrystallized from ethanol-water and dried to give a solid melting at 240°-241° C. (5.66 g, 93%).

Workup

  1. temperatureThe solution was cooled in ice
  2. filtrationthe product was filtered
  3. customdried
  4. customThe product was recrystallized from ethanol-water
  5. customdried

Sources & evidence

ORD record
ord-0b52892dd3f2488e974f133aacd21bf7
Source dataset
uspto-grants-1989_05
Patent number
US04835154

Reaction notes

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