Methyl iodide → 1-(3,5-Difluorobenzyl)-5-[(4-methyl-1-piperazinyl)methyl]imidazole 2-methylthioimidazole

HRID 1762804Notes

Reaction equation

HRID 1762804 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:20]=[C:21]([F:23])[CH:22]=1)[CH2:5][N:6]1[C:10]([CH2:11][N:12]2[CH2:17][CH2:16][N:15]([CH3:18])[CH2:14][CH2:13]2)=[CH:9][N:8]=[C:7]1[SH:19].[CH3:24]I.C[O-].[Na+]>CO>[F:1][C:2]1[CH:3]=[C:4]([CH:20]=[C:21]([F:23])[CH:22]=1)[CH2:5][N:6]1[C:10]([CH2:11][N:12]2[CH2:13][CH2:14][N:15]([CH3:18])[CH2:16][CH2:17]2)=[CH:9][N:8]=[CH:7]1.[CH3:24][S:19][C:7]1[NH:8][CH:9]=[CH:10][N:6]=1

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 10942334Sodium MethoxideHCID 1784808401-(3,5-Difluorobenzyl)-5-[(4-methyl-1-piperazinyl)methyl]-2-mercaptoimidazole

Product 1

HCID 703913731-(3,5-Difluorobenzyl)-5-[(4-methyl-1-piperazinyl)methyl]imidazole 2-methylthioimidazole

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Reaction of 1-(3,5-difluorobenzyl)-5-[(4-methyl-1-piperazinyl)methyl]imidazole-2-thiol prepared as in Example 1 with methyl iodide and sodium methoxide in methanol by known techniques yields 1-(3,5-difluorobenzyl)-5-[(4-methyl-1-piperazinyl)methyl]imidazole-2-methylthioimidazole.

Sources & evidence

ORD record
ord-3bc695aabb154fe0813b2552a4442823
Source dataset
uspto-grants-1989_05
Patent number
US04835154

Reaction notes

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