反应详情

温度

100 °C

A mixture of 6-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (2 g) and 1,4-naphthalenedione (3.4 g) in acetic anhydride (150 ml) was stirred in an oil bath at 100° C. for 15 minutes. It was then allowed to cool to room temperature and the green solid (2.74 g) was collected by filtration, washed with acetic anhydride and ether and dried at 100° C. for 2 h in vacuo, to give the title compound m.p. 275°-320° C. (decomp), λmax (in ethanol) 244.5 nm (ε26,220) 318 nm (ε4,510) and 383 nm (ε6,390).

1. temperatureto cool to room temperature
2. filtrationthe green solid (2.74 g) was collected by filtration
3. washwashed with acetic anhydride and ether
4. customdried at 100° C. for 2 h in vacuo