Butyl bromide → HCID 14500393, compound

HRID 1762831Notes

Reaction equation

[F:1][C:2]1[CH:28]=[CH:27][C:5]([C:6]([CH:8]2[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][N:16]3[C:21](=[O:22])[C:20]4[CH:23]=[CH:24][S:25][C:19]=4[NH:18][C:17]3=[O:26])[CH2:10][CH2:9]2)=[O:7])=[CH:4][CH:3]=1.Br[CH2:30][CH2:31][CH2:32][CH3:33]>>[CH2:30]([N:18]1[C:19]2[S:25][CH:24]=[CH:23][C:20]=2[C:21](=[O:22])[N:16]([CH2:15][CH2:14][N:11]2[CH2:12][CH2:13][CH:8]([C:6](=[O:7])[C:5]3[CH:4]=[CH:3][C:2]([F:1])=[CH:28][CH:27]=3)[CH2:9][CH2:10]2)[C:17]1=[O:26])[CH2:31][CH2:32][CH3:33]

Participants

Reactant 2

HCID 8002Butyl bromide

HCID 14500390HCID 14500390, compound

Product 1

HCID 14500393HCID 14500393, compoundYield 34%

Procedure

The title compound was prepared by the procedure of Example 14 using 2.0 g (5 mmol) of 3-[2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl]thieno[2,3-d]pyrimidine-2,4-dione from Example 2 and bromobutane (819 mg, 6 mmol). There was obtained 774 mg (34% yield) of the title compound as a yellow solid after recrystallization from CH2Cl2 /hexane, mp 124°-125° C.

Sources & evidence

ORD record: ord-d090489fd35d4d18b3a76b1ea16a7daf
Source dataset: uspto-grants-1989_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04835157

Reaction notes

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