HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → N-Methyl-4-(1-acetylpiperidin-4-yl)benzenesulphonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | 4-(1-Acetylpiperidin-4-yl)benzenesulphonyl chloride | HCID 20039820 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | N-Methyl-4-(1-acetylpiperidin-4-yl)benzenesulphonamide | HCID 20039839 | — |
Reaction Steps
Reaction of 4-(1-acetylpiperidin-4-yl)benzenesulphonyl chloride (16.0 g) [the product of Example 2(i)] with an excess of aqueous methylamine (100 ml, 30%) in ethanol (10 ml) according to the method of Example 2(ii) gave the title compound, (15.0 g), used directly in the next stage.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04835165 |
| Source dataset | uspto-grants-1989_05 |
| ORD ID | ord-4bb16e5bef79446fbce21595f8bf1372 |
| Source note | uspto-grants-1989_05 |