Methylamine → N-Methyl-4-(1-acetylpiperidin-4-yl)benzenesulphonamide

HRID 1762841Notes

Reaction equation

HRID 1762841 reaction equation
[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([C:10]2[CH:15]=[CH:14][C:13]([S:16](Cl)(=[O:18])=[O:17])=[CH:12][CH:11]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2].[CH3:20][NH2:21]>C(O)C>[CH3:20][NH:21][S:16]([C:13]1[CH:14]=[CH:15][C:10]([CH:7]2[CH2:8][CH2:9][N:4]([C:1](=[O:3])[CH3:2])[CH2:5][CH2:6]2)=[CH:11][CH:12]=1)(=[O:18])=[O:17]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 200398204-(1-Acetylpiperidin-4-yl)benzenesulphonyl chloride

Product 1

HCID 20039839N-Methyl-4-(1-acetylpiperidin-4-yl)benzenesulphonamide

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Reaction of 4-(1-acetylpiperidin-4-yl)benzenesulphonyl chloride (16.0 g) [the product of Example 2(i)] with an excess of aqueous methylamine (100 ml, 30%) in ethanol (10 ml) according to the method of Example 2(ii) gave the title compound, (15.0 g), used directly in the next stage.

Sources & evidence

ORD record
ord-4bb16e5bef79446fbce21595f8bf1372
Source dataset
uspto-grants-1989_05
Patent number
US04835165

Reaction notes

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