反应详情

温度

65 °C

21 g (0.103 mole) of N-(2-isopropylvinyl)-N-tert.-butylcarbamyl chloride are added dropwise to a suspension of 10.5 g (0.115 mole) of sodium 1,2,4-triazolide in 100 ml of dry tetrahydrofuran at 20° C. The mixture is stirred for 6 hours at 65° C., after which it is cooled to 20° C., the resulting precipitate is filtered off under suction, the filtrate is evaporated down and the oil which remains is distilled under reduced pressure. 13.6 g of 1-(N-(2-isopropylvinyl)-N-tert.-butylcarbamoyl)-1,2,4-triazole are obtained as a colorless liquid of boiling point 95°-97° C./0.15 mbar and nD 1.4815 (Compound No. 2)

1. temperatureafter which it is cooled to 20° C.
2. filtrationthe resulting precipitate is filtered off under suction
3. customthe filtrate is evaporated down
4. distillationthe oil which remains is distilled under reduced pressure