6-Bromohexanoyl chloride → HCID 14500511, compound

HRID 1762885Notes

Reaction equation

HRID 1762885 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][C:3]=1[F:9].[Br:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16](Cl)=[O:17]>>[Br:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]([NH:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][C:3]=1[F:9])=[O:17]

Participants

3

Reactant 2

HCID 898486-Bromohexanoyl chlorideHCID 27359194-Amino-3-fluorophenol

Product 1

HCID 14500511HCID 14500511, compoundYield 98%

Procedure

The 10.9 g (0.09 mol) of 4-amino-3-fluorophenol from above was reacted with 8.96 g (0.04 mol) of 6-bromo-hexanoyl chloride according to the procedure of Example 3, part a. 6-Bromo-N-(2-fluoro-4-hydroxyphenyl) hexanamide was obtained in 98% yield after crystallization from acetonitrile, mp 66°-69° C.

Sources & evidence

ORD record
ord-416ec1289f8944f4a691df5a1d327e5a
Source dataset
uspto-grants-1989_05
Patent number
US04835180

Reaction notes

Loading…