反应详情

This pyridine compound (5.18 g, 0.015 mole) was dissolved in the minimal amount of methanol and converted to the hydrochloride salt via ethereal hydrogen chloride. All solvents were removed and the volume was adjusted to 100 ml using methanol. To this methanol solution was added 1.4 g of platinum oxide and the reaction mixture was hydrogenated for 1 hr at room temperature. The methanol was removed by rotary evaporator and the residue was partitioned between dilute base and methylene chloride. Removal of methylene chloride gave 3.15 g (60% of the title compound as a red oil.

1. customAll solvents were removed
2. additionTo this methanol solution was added 1.4 g of platinum oxide
3. customThe methanol was removed by rotary evaporator
4. customthe residue was partitioned
5. additionbetween dilute base and methylene chloride
6. customRemoval of methylene chloride