HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 70381289, compound → HCID 70382369, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 70381289 | HCID 70381289 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 70382369 | HCID 70382369 | 97% |
Reaction Steps
Under the conditions of Example 14(E), 380 mg of 4-(2-n-butoxycarbonyl-1-methylethylaminoacetyl)-7-hydroxyindole-2-carboxylic acid n-butyl ester hydrochloride in 10 ml of methanol and 5 ml of tetrahydrofuran is hydrogenated and worked up, yielding 185 mg of 4-[1-hydroxy-2-(2-n-butoxycarbonyl-1-methylethylamino)ethyl]-7-hydroxyindole-2-carboxylic acid n-butyl ester hydrochloride, decomposition point 75°-84° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04835175 |
| Source dataset | uspto-grants-1989_05 |
| ORD ID | ord-77f4a26752bf4103887d4c4e3c991d2f |
| Source note | uspto-grants-1989_05 |