HCID 70381289, compound → HCID 70382369, compound

HRID 1762947Notes

Reaction equation

HRID 1762947 reaction equation
[ClH:1].[CH2:2]([O:6][C:7]([C:9]1[NH:10][C:11]2[C:16]([CH:17]=1)=[C:15]([C:18](=[O:31])[CH:19]([NH:27][CH:28]([CH3:30])[CH3:29])C(OCCCC)=O)[CH:14]=[CH:13][C:12]=2[OH:32])=[O:8])[CH2:3][CH2:4][CH3:5]>CO.O1CCCC1>[ClH:1].[CH2:2]([O:6][C:7]([C:9]1[NH:10][C:11]2[C:16]([CH:17]=1)=[C:15]([CH:18]([OH:31])[CH2:19][NH:27][CH:28]([CH3:30])[CH2:29][C:7]([O:6][CH2:2][CH2:3][CH2:4][CH3:5])=[O:8])[CH:14]=[CH:13][C:12]=2[OH:32])=[O:8])[CH2:3][CH2:4][CH3:5]

Participants

4

Reactant 1

HCID 70381289HCID 70381289, compound

Product 1

HCID 70382369HCID 70382369, compoundYield 97%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

Under the conditions of Example 14(E), 380 mg of 4-(2-n-butoxycarbonyl-1-methylethylaminoacetyl)-7-hydroxyindole-2-carboxylic acid n-butyl ester hydrochloride in 10 ml of methanol and 5 ml of tetrahydrofuran is hydrogenated and worked up, yielding 185 mg of 4-[1-hydroxy-2-(2-n-butoxycarbonyl-1-methylethylamino)ethyl]-7-hydroxyindole-2-carboxylic acid n-butyl ester hydrochloride, decomposition point 75°-84° C.

Sources & evidence

ORD record
ord-77f4a26752bf4103887d4c4e3c991d2f
Source dataset
uspto-grants-1989_05
Patent number
US04835175

Reaction notes

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