Hydrochloric Acid → 4-Allylaminoacetyl-7-hydroxyindole-2-carboxylic acid ethyl ester hydrochloride

HRID 1762951Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1762951
[CH2:1]([O:3][C:4]([C:6]1[NH:7][C:8]2[C:13]([CH:14]=1)=[C:12]([C:15](=[O:18])[CH2:16][Cl:17])[CH:11]=[CH:10][C:9]=2[OH:19])=[O:5])[CH3:2].[CH2:20]([NH2:23])[CH:21]=[CH2:22].Cl>CS(C)=O>[ClH:17].[CH2:1]([O:3][C:4]([C:6]1[NH:7][C:8]2[C:13]([CH:14]=1)=[C:12]([C:15](=[O:18])[CH2:16][NH:23][CH2:20][CH:21]=[CH2:22])[CH:11]=[CH:10][C:9]=2[OH:19])=[O:5])[CH3:2]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 7853AllylamineHCID 13243454Ethyl 4-(chloroacetyl)-7-hydroxy-1H-indole-2-carboxylate

Produkt 1

HCID 703814524-Allylaminoacetyl-7-hydroxyindole-2-carboxylic acid ethyl ester hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 679Dimethyl SulfoxideLösungsmittel

Versuchsvorschrift

2.8 g of 4-chloroacetyl-7-hydroxyindole-2-carboxylic acid ethyl ester is combined with 1.5 ml of allylamine and 15 ml of absolute dimethyl sulfoxide and stirred at room temperature for one hour. Then 150 ml of 2N hydrochloric acid is added to the reaction mixture, the immediately formed precipitate is vacuum-filtered, and the filtrate is allowed to stand and thus yields, in crystalline form, 1.5 g of 4-allylaminoacetyl-7-hydroxyindole-2-carboxylic acid ethyl ester hydrochloride, mp 264°-265° C. (decomposition).

Aufarbeitung

  1. filtrationthe immediately formed precipitate is vacuum-filtered

Quellen und Nachweise

ORD-Eintrag
ord-444fef2c936349cd92750662735f920a
Quelldatensatz
uspto-grants-1989_05
Patentnummer
US04835175

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