反应详情

2.8 g of 4-chloroacetyl-7-hydroxyindole-2-carboxylic acid ethyl ester is combined with 1.5 ml of allylamine and 15 ml of absolute dimethyl sulfoxide and stirred at room temperature for one hour. Then 150 ml of 2N hydrochloric acid is added to the reaction mixture, the immediately formed precipitate is vacuum-filtered, and the filtrate is allowed to stand and thus yields, in crystalline form, 1.5 g of 4-allylaminoacetyl-7-hydroxyindole-2-carboxylic acid ethyl ester hydrochloride, mp 264°-265° C. (decomposition).

1. filtrationthe immediately formed precipitate is vacuum-filtered