HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-Allylaminoacetyl-7-hydroxyindole-2-carboxylic acid ethyl ester hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Allylamine | HCID 7853 | — |
| Reactant | Ethyl 4-(chloroacetyl)-7-hydroxy-1H-indole-2-carboxylate | HCID 13243454 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 4-Allylaminoacetyl-7-hydroxyindole-2-carboxylic acid ethyl ester hydrochloride | HCID 70381452 | — |
Reaction Steps
2.8 g of 4-chloroacetyl-7-hydroxyindole-2-carboxylic acid ethyl ester is combined with 1.5 ml of allylamine and 15 ml of absolute dimethyl sulfoxide and stirred at room temperature for one hour. Then 150 ml of 2N hydrochloric acid is added to the reaction mixture, the immediately formed precipitate is vacuum-filtered, and the filtrate is allowed to stand and thus yields, in crystalline form, 1.5 g of 4-allylaminoacetyl-7-hydroxyindole-2-carboxylic acid ethyl ester hydrochloride, mp 264°-265° C. (decomposition).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04835175 |
| Source dataset | uspto-grants-1989_05 |
| ORD ID | ord-444fef2c936349cd92750662735f920a |
| Source note | uspto-grants-1989_05 |