HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 3-(benzylamino)-3-methylbutanoate → 4-[N-benzyl-N-(2-ethoxycarbonyl-1,1-dimethylethyl)aminoacetyl]-7-hydroxyindole-2-carboxylic acid ethyl ester hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 3-(benzylamino)-3-methylbutanoate | HCID 288946 | — |
| Reactant | Ethyl 4-(chloroacetyl)-7-hydroxy-1H-indole-2-carboxylate | HCID 13243454 | — |
| Product | 4-[N-benzyl-N-(2-ethoxycarbonyl-1,1-dimethylethyl)aminoacetyl]-7-hydroxyindole-2-carboxylic acid ethyl ester hydrochloride | HCID 70381467 | 15.9% |
Reaction Steps
Under the conditions of Example 28, 2.57 g of 4-chloroacetyl-7-hydroxyindole-2-carboxylic acid ethyl ester is reacted with 2.35 g of 3-benzylamino-3-methylbutyric acid ethyl ester and worked up, yielding 0.75 g of 4-[N-benzyl-N-(2-ethoxycarbonyl-1,1-dimethylethyl)aminoacetyl]-7-hydroxyindole-2-carboxylic acid ethyl ester hydrochloride, decomposition point 210°-212° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04835175 |
| Source dataset | uspto-grants-1989_05 |
| ORD ID | ord-97730f51818f4c69874a30141c7f4ad7 |
| Source note | uspto-grants-1989_05 |