HCID 54416050, compound → HCID 70382016, compound

HRID 1762964Notes

Reaction equation

HRID 1762964 reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][CH2:8][O:9][C:10]([C:12]2[NH:13][C:14]3[C:19]([CH:20]=2)=[C:18]([C:21](=[O:35])[CH2:22][N:23](CC2C=CC=CC=2)[C:24]([CH3:27])([CH3:26])[CH3:25])[CH:17]=[CH:16][C:15]=3[O:36]CC2C=CC=CC=2)=[O:11])[CH2:3][CH2:2]1>CO.C(OCC)C>[C:10]([OH:11])(=[O:9])[CH3:12].[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][CH2:8][O:9][C:10]([C:12]2[NH:13][C:14]3[C:19]([CH:20]=2)=[C:18]([CH:21]([OH:35])[CH2:22][NH:23][C:24]([CH3:25])([CH3:26])[CH3:27])[CH:17]=[CH:16][C:15]=3[OH:36])=[O:11])[CH2:3][CH2:2]1

Participants

3

Reactant 1

HCID 54416050HCID 54416050, compound

Product 1

HCID 70382016HCID 70382016, compoundYield 153.7%

Reagents, catalysts & solvents 1

HCID 21864698Diethyl ether methanolSolvent

Procedure

408 mg of 7-benzyloxy-4-(N-benzyl-N-tert-butylaminoacetyl)indole-2-carboxylic acid 2-(morpholino)ethyl ester is hydrogenated under the conditions of Example 14(E) and worked up, thus obtaining 250 mg of 7-hydroxy-4-(1-hydroxy-2-tert-butylaminoethyl)indole-2-carboxylic acid 2-(morpholino)ethyl ester monoacetate, decomposition point 177°-177.5° C. (from methanol/diethyl ether).

Sources & evidence

ORD record
ord-6daeccb88e074d288075f7aeb1aefbac
Source dataset
uspto-grants-1989_05
Patent number
US04835175

Reaction notes

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