HCID 13935155, compound → 1-Acridinol, 1,2,3,4-tetrahydro-9-amino-6-(trifluoromethyl)-

HRID 1763029Notes

Reaction equation

HRID 1763029 reaction equation
[NH2:1][C:2]1[C:3]2[C:8]([N:9]=[C:10]3[C:15]=1[C:14](=[O:16])[CH2:13][CH2:12][CH2:11]3)=[CH:7][C:6]([C:17]([F:20])([F:19])[F:18])=[CH:5][CH:4]=2.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[NH2:1][C:2]1[C:3]2[C:8]([N:9]=[C:10]3[C:15]=1[CH:14]([OH:16])[CH2:13][CH2:12][CH2:11]3)=[CH:7][C:6]([C:17]([F:20])([F:18])[F:19])=[CH:5][CH:4]=2

Participants

4

Reactant 2

HCID 13935155HCID 13935155, compoundHCID 21226445Aluminium lithium hydride

Product 1

HCID 30256081-Acridinol, 1,2,3,4-tetrahydro-9-amino-6-(trifluoromethyl)-

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

9Amino-3,4-dihydro-6trifluoromethylacridin-1(2H)-one (2.4 g) was suspended in 60 ml of tetrahydrofuran. To this cooled solution was added 9 ml of 1 molar solution of lithium aluminium hydride in THF. This was stirred for 30 minutes.

Sources & evidence

ORD record
ord-4f995ec80ab1400c834341bf708b3d19
Source dataset
uspto-grants-1989_05
Patent number
US04835275

Reaction notes

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