p-Anisoyl chloride → HCID 14365673, compound

HRID 1763071Notes

Reaction equation

HRID 1763071 reaction equation
[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:6]([C:7](Cl)=[O:8])=[CH:5][CH:4]=1.[F:12][C:13](I)([C:18]([F:21])([F:20])[F:19])[C:14]([F:17])([F:16])[F:15]>C(Cl)Cl>[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:6]([C:7](=[O:8])[C:13]([F:12])([C:18]([F:21])([F:20])[F:19])[C:14]([F:17])([F:16])[F:15])=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 7477p-Anisoyl chlorideHCID 33978Perfluoroisopropyl iodide

Product 1

HCID 14365673HCID 14365673, compoundYield 76%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
-10 °C

Procedure

Under protective gas, 27.3 g (0.16 mol) of p-methoxybenzoyl chloride and 53.3 g (0.18 mol) of perfluoroisopropyl iodide in 150 ml of CH2Cl2 are initially introduced into a round-bottomed flask. 45 g (0.18 mol) of phosphorous acid trisdiethylamide are metered in at about -20° C. during the course of 3 hours. The mixture is subsequently stirred at about -10° C. for 5 hours and, after warming, worked up analogously to Example 1. 37 g (76%) of 1-(4-methoxyphenyl)-2,3,3,3-tetrafluoro-2-trifluoromethylpropan-1-one of b.p. 97°-99° C./10 mbar are obtained.

Workup

  1. customare metered in at about -20° C. during the course of 3 hours
  2. temperatureafter warming

Sources & evidence

ORD record
ord-712824d1791244438a3b32da0060f675
Source dataset
uspto-grants-1989_05
Patent number
US04835318

Reaction notes

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