p-Anisoyl chloride → HCID 14365673, compound

Participants

Reaction Conditions

Reaction Steps

Under protective gas, 27.3 g (0.16 mol) of p-methoxybenzoyl chloride and 53.3 g (0.18 mol) of perfluoroisopropyl iodide in 150 ml of CH2Cl2 are initially introduced into a round-bottomed flask. 45 g (0.18 mol) of phosphorous acid trisdiethylamide are metered in at about -20° C. during the course of 3 hours. The mixture is subsequently stirred at about -10° C. for 5 hours and, after warming, worked up analogously to Example 1. 37 g (76%) of 1-(4-methoxyphenyl)-2,3,3,3-tetrafluoro-2-trifluoromethylpropan-1-one of b.p. 97°-99° C./10 mbar are obtained.

Provenance & Evidence