反应详情

温度

-78 °C

This material was prepared in 52.7% yield from 0.06 mol of LDA and 0.024 mol of product of Example 6 according to the following general procedure as a beige solid, mp 115°-117° C. To a -78° C. solution of 2.5 eq (0.06 mol) of LDA in DMEwas added a solution of 1 eq (0.024 mol) of starting material, the monocarboxylate product (Example 6) in dry DME. The resulting dark colored solution was stirred for 30 minutes at -78° C. To the above solution was added excess of dry ice. The reaction mixture was stirred at -78° C. for 15 minutes and warmed to room temperature in 1 hour. The reaction mixture was poured into ice water (100 ml) and extracted with ether. The aqueous layer was made acidic. The oil precipitate was extracted with ether. The ether extract was dried (MgSO4) and concentrated in vacuo to give the desired product.

1. stirringThe reaction mixture was stirred at -78° C. for 15 minutes
2. temperaturewarmed to room temperature in 1 hour
3. extractionextracted with ether
4. extractionThe oil precipitate was extracted with ether
5. extractionThe ether extract
6. dry with materialwas dried (MgSO4)
7. concentrationconcentrated in vacuo