反应详情

Two grams of the product of Example I (0.0118 mole), 2.2 g. (0.0118 mole) of 3-trifluoromethylphenylisocyanate, and 100 ml. of acetonitrile are combined in a 250 ml. Erlenmeyer flask. The mixture is magnetically stirred, and 1.9 g. (0.0118 mole) of triethylamine are then added. The resulting mixture is stirred at room temperature for one hour and then poured into 300 ml. of ice water. The crystalline product is collected by filtration and dried to yield 2.0 g. (53% of theory) of the title compound, mp = 96°-99° C. Structure is confirmed by IR and NMR.

1. stirringThe resulting mixture is stirred at room temperature for one hour
2. additionpoured into 300 ml
3. filtrationThe crystalline product is collected by filtration
4. customdried
5. customto yield 2.0 g