Methyl iodide → N-Butyl-N'-(5-tert-butyl-1,2-oxazol-3-yl)-N,N'-dimethylurea

HRID 1763195Notes

Reaction equation

[CH3:1][N:2]([CH2:15][CH2:16][CH2:17][CH3:18])[C:3]([NH:5][C:6]1[CH:10]=[C:9]([C:11]([CH3:14])([CH3:13])[CH3:12])[O:8][N:7]=1)=[O:4].[CH3:19]I>>[CH3:1][N:2]([CH2:15][CH2:16][CH2:17][CH3:18])[C:3]([N:5]([CH3:19])[C:6]1[CH:10]=[C:9]([C:11]([CH3:12])([CH3:13])[CH3:14])[O:8][N:7]=1)=[O:4]

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 20534526N-Butyl-N'-(5-tert-butyl-1,2-oxazol-3-yl)-N-methylurea

Product 1

HCID 22768164N-Butyl-N'-(5-tert-butyl-1,2-oxazol-3-yl)-N,N'-dimethylurea

Procedure

The reaction is effected as in Example 171 by using 1-methyl-1-butyl-3-(5-t-butyl-3-isoxazolyl)urea and methyl iodide to give 1,3-dimethyl-1-butyl-3-(5-t-butyl-3-isoxazolyl)urea as an oil boiling at 130° to 135° C. (bath temperature)/0.25 mm Hg.

Sources & evidence

ORD record: ord-f432c8a560c340b1b1c7467db15b7b34
Source dataset: uspto-grants-1978_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04111680

Reaction notes

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